Microketides A and B, Polyketides from a Gorgonian-Derived <i>Microsphaeropsis</i> sp. Fungus
Yunfeng Liu, Yahui Zhang, Chang‐Lun Shao, Fei Cao, Chang‐Yun Wang
Abstract
Microketides A and B (1 and 2), a pair of new C-11 epimeric polyketides, were obtained from the gorgonian-derived fungus Microsphaeropsis sp. RA10-14 collected from the South China Sea. The absolute configurations of 1 and 2 were assigned by the modified Mosherʼs method, TDDFT-ECD, and NMR calculations. Compounds 1 and 2 were evaluated for antibacterial, antifungal, and growth inhibition of marine phytoplankton activities. Microketide A (1) exhibited promising inhibitory activity against Pseudomonas aeruginosa, Nocardia brasiliensis, Kocuria rhizophila, and Bacillus anthraci with the same MIC value as ciprofloxacin (0.19 μg/mL).
Topics & Concepts
GorgonianStereochemistryFungusAbsolute configurationMicrobiologyBiologyAntibacterial activityChemistryBacteriaBotanyEcologyGeneticsCoralMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsGenomics and Phylogenetic Studies