Metabolomic profile of medicinal plants with anti-RVFV activity
Garland K. More, Jacques Vervoort, Paul A. Steenkamp, Gerhard Prinsloo
Abstract
295.2274 13S-Hydroxy-9Z,11E,15Z-octadecatrienoic acid and 13-Hydroxy-9Z,11E-octadecadienoic acid were annotated for the first time in all the antiviral active samples and are considered potential metabolites responsible for the antiviral activity. The study provides a metabolomic profile of anti-RVFV plant extracts and report for the first time the presence of hydroxylated fatty acids 13S-Hydroxy-9Z,11E,15Z-octadecatrienoic acid and 13-Hydroxy-9Z,11E-octadecadienoic acid, present in all the tested medicinal plants with high anti-RVFV activity and is a potential target for the future development of antiviral therapeutic agents.
Topics & Concepts
MetabolomicsMetabolomeChemistryChemometricsOPLSTrigonellineChromatographyPartial least squares regressionVanillic acidChlorogenic acidMetaboliteBiochemistryStatisticsHydrogen bondMathematicsMoleculeOrganic chemistryPhytochemistry and Biological ActivitiesMetabolomics and Mass Spectrometry StudiesNatural product bioactivities and synthesis