Gut microbiota in ischemic stroke: Where we stand and challenges ahead
Jia-Xin Long, Jinlong Wang, Yang Li, Daiwen Chen
Abstract
Gut microbiota is increasingly recognized to affect host health and disease, including ischemic stroke (IS). Here, we systematically review the current understanding linking gut microbiota as well as the associated metabolites to the pathogenesis of IS (e.g., oxidative stress, apoptosis, and neuroinflammation). Of relevance, we highlight that the implications of gut microbiota-dependent intervention could be harnessed in orchestrating IS.
Topics & Concepts
NeuroinflammationGut floraStroke (engine)Oxidative stressDiseasePathogenesisGut–brain axisNeuroscienceIschemic strokeBioinformaticsMedicineBiologyImmunologyInflammationIschemiaInternal medicineMechanical engineeringEngineeringGut microbiota and healthTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms