Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies
Abdallah M. Alfayomy, Salah A. Abdel‐Aziz, Adel A. Marzouk, Montaser Sh. A. Shaykoon, Atsushi Narumi, Hiroyuki Konno, Sahar M. Abou‐Seri, Fatma A.F. Ragab
Topics & Concepts
ChemistryCelecoxibIn vivoDocking (animal)PyrimidineActive siteCoumarinStereochemistryPharmacologyAnti-inflammatoryIC50In vitroBiochemistryEnzymeOrganic chemistryMedicineNursingBiologyBiotechnologySynthesis and biological activitySynthesis and Biological EvaluationInflammatory mediators and NSAID effects