Coronavirus Porcine Deltacoronavirus Upregulates MHC Class I Expression through RIG-I/IRF1-Mediated NLRC5 Induction
Xiang Liu, Lingdan Yin, Mei Xue, Jianfei Chen, Liang Li, Fang Fu, Li Feng, Pinghuang Liu
Abstract
MHC-I molecules play a crucial role in antiviral immunity by presenting intracellular antigens to CD8 + T lymphocytes and eliminating virus-infected cells by natural killer cells’ “missing-self recognition.” However, the manipulation of MHC molecules by coronaviruses remains poorly understood. Here, we demonstrated that PDCoV, a zoonotic potential coronavirus efficiently infecting cells from broad species, greatly increased the expressions of porcine MHC-I (SLA-I) molecules and MHC-I antigen presentation associated genes but not porcine MHC-II (SLA-II) molecules both in vitro and in vivo .
Topics & Concepts
BiologyIRF1Antigen processingMajor histocompatibility complexMHC class IAntigen presentationMHC class IICD8Downregulation and upregulationInterferon gammaCell biologyAntigenVirologyImmunologyImmune systemT cellGene expressionGeneGeneticsAnimal Virus Infections StudiesImmune Cell Function and Interactioninterferon and immune responses