Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine <i>O</i>-Acetyltransferase Inhibitor
Joana Magalhães, Nina Franko, Samanta Raboni, Giannamaria Annunziato, Päivi Tammela, Agostino Bruno, Stefano Bettati, Andrea Mozzarelli, Marco Pieroni, Barbara Campanini, Gabriele Costantino
Abstract
<100 μM were identified via an indirect assay using Ellman's reagent and then tested on a Gram-negative model organism, with one of them being able to interfere with bacterial growth via SAT inhibition.
Topics & Concepts
SerineAcetyltransferaseChemistryComputational biologyBiochemistryBiologyEnzymeGeneAcetylationEnzyme Structure and FunctionEnzyme Production and CharacterizationCancer Research and Treatments