Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling
Marcus E. Graziotto, Liam D. Adair, Amandeep Kaur, Pauline M. Vérité, Sarah R. Ball, Margaret Sunde, Denis Jacquemin, Elizabeth J. New
Abstract
, providing a new method that can monitor their growth kinetics and morphology. Since our synthetic approach is simple and modular, these new naphthalimide tetrazines provide a novel scaffold for a range of bioorthogonal tetrazine-based imaging agents for selective staining and sensing of biomolecules.
Topics & Concepts
Bioorthogonal chemistryTetrazineBiomoleculeChemistryFluorescenceCombinatorial chemistryLabellingBioconjugationLinkerFluorescence-lifetime imaging microscopyMolecular imagingClick chemistryBiochemistryIn vivoComputer scienceOrganic chemistryBiologyQuantum mechanicsBiotechnologyPhysicsOperating systemClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesMonoclonal and Polyclonal Antibodies Research