A Functional Screening Strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation
Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Samara Frey, David Egli, Rodrigo Vazquez-Lombardi, Edo Kapetanovic, Jakub Kucharczyk, Sai T. Reddy
Topics & Concepts
Chimeric antigen receptorReceptorAntigenComputational biologyCell biologyBiologyChemistryComputer scienceImmunologyImmunotherapyBiochemistryImmune systemCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchNanofabrication and Lithography Techniques