Two new alkaloids from Tibetan medicine of <i>Hypecoum leptocarpum</i>
Bo Sun, Israa Assani, Chun‐Gu Wang, Mu-xuan Wang, Ling‐Fei Liu, Yan Li, Ge Yan, Yun-Ruo Yang, Zhi Chen, Zhi‐Xin Liao
Abstract
Two new alkaloids, leptocarpinine B (1) and corydamine acid (2), with thirteen known alkaloid compounds (3–15), were isolated from Hypecoum leptocarpum. The structures of the isolated compounds were determined based on spectroscopic data analyses, including IR, ESI-MS, 1 D, and 2 D NMR. In addition, all the isolates were evaluated for cytotoxic activities. Compound 6 showed moderate cytotoxicity against human ovarian cancer cell lines (A2780), human cervical cancer cell lines (HeLa), and human hepatocellular carcinomas cell lines (HepG2).
Topics & Concepts
HeLaCytotoxicityStereochemistryCell cultureAlkaloidCytotoxic T cellCancer cell linesChemistryTraditional medicineBiologyCellCancer cellCancerBiochemistryIn vitroMedicineGeneticsBioactive natural compoundsBerberine and alkaloids researchAlkaloids: synthesis and pharmacology