False-positive and false-negative COVID-19 cases: respiratory prevention and management strategies, vaccination, and further perspectives
Dimitra S. Mouliou, Konstantinos I. Gourgoulianis
Abstract
: The diagnostic accuracy and the capacity of every available assay, which need to be interpreted in the light of the background incidence of SARS-CoV-2 infection in the communities in which they are used, are essential in order to minimize the number of falsely tested cases. Automated testing platforms may enhance diagnostic accuracy by minimizing the potential for human error in assays' performance. Prior immunization against SARS-CoV-2 impairs the utility of serologic testing of suspected COVID-19 cases. Future avenues of research to evaluate lung tissue innate immune responses hold promise as a target for research to optimize SARS-CoV-2 and future infections' testing accuracy.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Intensive care medicineVaccination2019-20 coronavirus outbreakCoronavirusRespiratory systemFalse Negative ReactionsImmunologyVirologyPathologyOutbreakInternal medicineDiseaseInfectious disease (medical specialty)SARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 ResearchRespiratory viral infections research