Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids
Jan Fröhlich, Marco Raffaele, Helena Skálová, Eric Leire, Illar Pata, Pille Pata, Vera Gorbunova, Manlio Vinciguerra
Topics & Concepts
SIRT6BiologySteatohepatitisNonalcoholic fatty liver diseaseCentenarianCancer researchFatty liverLipotoxicitySirtuinHepatic stellate cellEndocrinologyGeneticsInternal medicineInsulin resistanceGeneLongevityMedicineDiseaseAcetylationInsulinLiver Disease Diagnosis and TreatmentSirtuins and Resveratrol in MedicineBiochemical effects in animals