New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
May Thazin Thant, Nutputsorn Chatsumpun, Wanwimon Mekboonsonglarp, Boonchoo Sritularak, Kittisak Likhitwitayawuid
Abstract
Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3–9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase.
Topics & Concepts
AcarboseDendrobiumChemistryInhibitory postsynaptic potentialNon-competitive inhibitionEnzymeFluoreneStereochemistryGlucosidasesBiochemistryOrganic chemistryBiologyBotanyPolymerNeuroscienceBiological and pharmacological studies of plantsBioactive natural compoundsGinseng Biological Effects and Applications