Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease
Nilanjan Ghosh, Sonya Fenton, Isabelle van Hout, Gregory T. Jones, Sean Coffey, Michael Williams, Ramanen Sugunesegran, Dominic Parry, Philip J. Davis, Daryl O. Schwenke, Anirudha Chatterjee, Rajesh Katare
Abstract
knockdown of miR-320 in 24-week-old type 2 diabetic db/db mice reduced cardiomyocyte apoptosis and interstitial fibrosis while restoring vascular density. This resulted in partial recovery of the impaired diastolic and systolic function. Our study provides evidence that miR-320 is a late-responding miRNA that aggravates apoptosis and cardiac dysfunction in the diabetic heart, and that therapeutic knockdown of miR-320 is beneficial in partially restoring the deteriorated cardiac function.
Topics & Concepts
Gene knockdownMedicineCardiologyDiseaseCardiac function curveInternal medicineFunction (biology)Diabetes mellitusHeart failureEndocrinologyChemistryBiologyApoptosisBiochemistryEvolutionary biologyCardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingCardiovascular Disease and Adiposity