Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation
Wen-Jun Yu, Busong Wang, Liang Zhou, Guoqiang Xu
Abstract
knockdown completely abolishes the inhibitory effect of p62 on c-Jun. Using brefeldin A as an inducer of ER stress, we demonstrate that the p62/c-Jun axis participates in the regulation of ER stress-induced apoptosis, and that CRBN is required for this regulation. In summary, we have identified an upstream signaling pathway, which regulates p62-mediated c-Jun degradation. Our findings elucidate the underlying molecular mechanism by which p62/c-Jun axis regulates the ER stress-induced apoptosis, and provide a new molecular connection between ER stress and apoptosis.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseDownregulation and upregulationCell biologyUbiquitin ligaseEndoplasmic-reticulum-associated protein degradationGene knockdownUbiquitinChemistryCullinc-junSignal transductionProteasomeApoptosisBiologyTranscription factorBiochemistryGeneAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathways