Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors
Manasa Kadagathur, Arbaz Sujat Shaikh, Biswajit Panda, Joel George, Regur Phanindranath, Dilep Kumar Sigalapalli, Nagesh A. Bhale, Chandraiah Godugu, Narayana Nagesh, Nagula Shankaraiah, Neelima D. Tangellamudi
Topics & Concepts
ChemistryADMECytotoxicityClonogenic assayCancer cellCytotoxic T cellApoptosisIC50PharmacologyCancerBiochemistryStereochemistryCancer researchIn vitroBiologyGeneticsCancer therapeutics and mechanismsSynthesis and bioactivity of alkaloidsSynthesis and pharmacology of benzodiazepine derivatives