The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and Membranous Nephropathy
Lihong Bu, Samar M. Said, Loren Herrera Hernandez, Zohreh Mohammad Taheri, Leslie Spry, Brett S. Rosenthal, Arjun Das, Benjamin Madden, Christopher P. Larsen, Youngki Kim, Sanjeev Sethi, Samih H. Nasr
Abstract
Concurrent anti-glomerular basement membrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients)1-3. The target antigen(s) in MN associated with anti-GBM nephritis are unknown. We report the clinicopathologic characteristics and outcome of 28 patients with this dual glomerulopathy, which were among 449 (6.2%) anti-GBM nephritis and 5183 (0.5%) non-lupus MN cases diagnosed at a large nephropathology laboratory over a 23-year period (Supplementary methods).
Topics & Concepts
Membranous nephropathyMedicineGlomerulopathyGlomerular basement membraneNephritisLupus nephritisBasement membraneGlomerulonephritisPathologyInternal medicineKidneyDiseaseRenal Diseases and GlomerulopathiesVasculitis and related conditionsAmyloidosis: Diagnosis, Treatment, Outcomes