Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors
Dima A. Sabbah, Rima Hajjo, Kamal Sweidan
Abstract
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
Topics & Concepts
Epidermal growth factor receptorERBB3Cancer researchGrowth factor receptor inhibitorSignal transductionErbBCyclin-dependent kinase 8Epidermal growth factorTyrosine kinaseRegulatorReceptor tyrosine kinaseEGFR inhibitorsGrowth factor receptorCell biologyBiologyReceptorChemistryBiochemistryGeneNotch signaling pathwayHER2/EGFR in Cancer ResearchLung Cancer Treatments and MutationsColorectal Cancer Treatments and Studies