Angiogenesis–osteogenesis coupling and immunomodulatory CGRP@nano MOF-loaded CMCS/GelMA hydrogel for bone regeneration
Rong Luo, Chen Zhao, Man Zhe, Wenting Wu, Yuzhen Xiao, Jiabao Jiang, Hao Liu, Ming Liu, Fei Xing
Abstract
assessments indicated that the CGRP@MOF/CG hydrogel significantly regulated the local immune microenvironment and accelerated the healing of cranial defects in rat models. This study provides valuable references for the design and fabrication of multifunctional materials for enhancing bone regeneration.
Topics & Concepts
Regeneration (biology)Self-healing hydrogelsMaterials scienceAngiogenesisCalcitonin gene-related peptideBiomedical engineeringNano-Cell biologyComposite materialMedicinePolymer chemistryCancer researchInternal medicineNeuropeptideBiologyReceptorBone Tissue Engineering Materials3D Printing in Biomedical ResearchGraphene and Nanomaterials Applications