Polymer nanoparticles regulate macrophage repolarization for antitumor treatment
Xuancheng Fu, Jiamu Yu, Anran Yuan, Libing Liu, Hao Zhao, Yiming Huang, Song Shen, Fengting Lv, Shu Wang
Abstract
We demonstrate an intrinsic antitumor effect of polymer nanoparticles (P-NPs), which could re-program tumor-associated macrophages to pro-inflammatory phenotype. The intrinsic effect of P-NPs on macrophage repolarization and its combination with other therapies provide new ideas for drug delivery, macrophage regulation and immunotherapy in cancer treatment.
Topics & Concepts
MacrophageImmunotherapyNanoparticleCancer immunotherapyDrugRepolarizationCancer researchChemistryCancerPolymerPharmacologyMedicineNanotechnologyMaterials scienceInternal medicineBiochemistryIn vitroElectrophysiologyOrganic chemistryImmune cells in cancerNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery