The Future of Medicinal Chemistry, PROTAC, and Undruggable Drug Targets
Antti Poso
Abstract
WRD5 is a promising target for anticancer drug discovery. In addition, it plays a vital role in epigenetic regulation. Since biological inactivation of WRD5 is difficult to reach via classical approach, PROTACs (Proteolysis Targeting Chimeras) are offering a new option. In a study, published in this journal, new WRD5 targeting PROTACS are introduced. These new compounds, which are also active in cells, make it possible to evaluate the value of WRD5 as a drug target.
Topics & Concepts
ChemistryDrug discoveryDrugEpigeneticsComputational biologyAnticancer drugPharmacologyBiochemistryBiologyGeneProtein Degradation and InhibitorsHistone Deacetylase Inhibitors Research14-3-3 protein interactions