Palladium catalyzed synthesis of indolizines <i>via</i> the carbonylative coupling of bromopyridines, imines and alkynes
Sébastien A. Roy, José Zgheib, Cuihan Zhou, Bruce A. Arndtsen
Abstract
the carbonylative formation of a high energy, mesoionic pyridine-based 1,3-dipole, which can undergo spontaneous cycloaddition with alkynes. Overall, this provides a route to prepare indolizines in a modular fashion from combinations of commercially available or easily generated reagents: 2-bromopyridines, imines and alkynes.
Topics & Concepts
PalladiumCatalysisChemistryCoupling (piping)CarbonylationCombinatorial chemistryOrganic chemistryMaterials scienceCarbon monoxideMetallurgySynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods