Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection
Jie Jiang, Jiangqing Chen, Chan Liao, Yanting Duan, Yajie Wang, Kai Shang, Yanjie Huang, Yongming Tang, Xiaofei Gao, Ying Gu, Jie Sun
Topics & Concepts
Cancer researchBiologyChimeric antigen receptorT-cell leukemiaLeukemiaT cellImmunologyImmune systemCAR-T cell therapy researchVirus-based gene therapy researchCRISPR and Genetic Engineering