Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk
Sarah Lazzaro, Mark A. West, Soraya Eatemadpour, Bo Feng, Manthena V. S. Varma, A. David Rodrigues, Csilla Temesszentandrási‐Ambrus, P Kovács, Zsuzsanna Nerada, Zsuzsanna Gáborik, Chester Costales
Topics & Concepts
In vivoPotencyIC50P-glycoproteinPharmacologyIn vitroEffluxIntracellularDrugIn vitro toxicologyChemistryVesicleCell cultureBiologyBiochemistryMembraneMultiple drug resistanceBiotechnologyGeneticsAntibioticsDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPregnancy and Medication Impact