MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer
Jun Liu, Szu-Jung Chen, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C.H. Yang, Shenwen Gu, Kent E. Pinkerton, Ching‐Hsien Chen
Abstract
Our results suggest that phospho-MARCKS is a novel NF-kB activator in smoke-mediated lung cancer progression and provide a promising molecular model for developing new anticancer strategies.
Topics & Concepts
MARCKSPhosphorylationCancer researchLung cancerSignal transductionEpithelial–mesenchymal transitionBiologyA549 cellMedicineCell biologyDownregulation and upregulationChemistryProtein kinase CPathologyBiochemistryGeneNF-κB Signaling PathwaysGenomics, phytochemicals, and oxidative stressCancer-related molecular mechanisms research