Macrophages direct location-dependent recall of B cell memory to vaccination
Rama Dhenni, Alexandra Carey Hoppé, Arnold Reynaldi, Wunna Kyaw, Nathalie Tricia Handoko, Abigail K. Grootveld, Yuki Honda Keith, Nayan D. Bhattacharyya, Holly I. Ahel, Aiden Telfser, Andrew N. McCorkindale, Seyhan Yazar, C. Bui, James T. Smith, Weng Hua Khoo, Mollie Ailie Acheson Boyd, Solange Obeid, Brad Milner, Mitchell Starr, Fabienne Brilot, Vanessa Milogiannakis, Anouschka Akerman, Anupriya Aggarwal, Miles P. Davenport, Elissa K. Deenick, Christine L. Chaffer, Peter I. Croucher, Robert Brink, Leonard D. Goldstein, Deborah Cromer, Stuart Turville, Anthony D. Kelleher, Vanessa Venturi, C. Mee Ling Munier, Tri Giang Phan
Abstract
subcapsular sinus macrophages (SSMs) in the subcapsular niche. In human participants, boosting of the BNT162b2 vaccine in the same arm generated more rapid secretion of broadly neutralizing antibodies, GC participation, and clonal expansion of SARS-CoV-2-specific B cells than boosting of the opposite arm. These data reveal an unappreciated role for primed draining lymph node SSMs in Bmem cell fate determination.