Strong, tough, and elastic poly(vinyl alcohol)/polyacrylamide DN hydrogels based on the Hofmeister effect for articular cartilage replacement
Cheng Xian Yin, Zhiwu Huang, Yunge Zhang, Kaijing Ren, Song‐Tao Liu, Honglin Luo, Quanchao Zhang, Yizao Wan
Abstract
, respectively, which were the highest strength and modulus, and the second highest toughness when compared with those of the reported PVA and PVA based DN hydrogels so far. It also showed an extreme high elasticity, which could maintain a stress of 99.2% after 500 cycles of fatigue testing. Additionally, PVA/PAM-Cit can promote the adhesion, spreading and proliferation of chondrocytes. These results verify that such a strong, tough, and elastic hydrogel could be a novel candidate material for articular cartilage replacement.
Topics & Concepts
Self-healing hydrogelsVinyl alcoholArticular cartilageMaterials sciencePolyacrylamideBrittlenessCartilageComposite materialPolymerPolymer chemistryAnatomyMedicineOsteoarthritisPathologyAlternative medicineHydrogels: synthesis, properties, applicationsOsteoarthritis Treatment and MechanismsAdvanced Fiber Optic Sensors