Ultrafast 2D <sup>1</sup>H–<sup>1</sup>H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
Kawarpal Singh, Corentin Jacquemmoz, Patrick Giraudeau, Lucio Frydman, Jean‐Nicolas Dumez
Abstract
We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.
Topics & Concepts
Ultrashort pulseNuclear magnetic resonance spectroscopyNMR spectra databaseSpectroscopyChemistrySpectral lineDissolutionAnalytical Chemistry (journal)Two-dimensional nuclear magnetic resonance spectroscopyPhysical chemistryPhysicsStereochemistryChromatographyLaserAstronomyOpticsQuantum mechanicsAdvanced NMR Techniques and ApplicationsSolid-state spectroscopy and crystallographyNMR spectroscopy and applications