Unravelling the sex-specific diversity and functions of adrenal gland macrophages
Bastien Dolfi, Alexandre Gallerand, Maria Firulyova, Yingzheng Xu, Johanna Merlin, Adélie Dumont, Alexia Castiglione, Nathalie Vaillant, Sandrine Quemener, Heidi Gerke, Marion I. Stunault, Patricia R. Schrank, Seung Hyeon Kim, Alisha Zhu, Jie Ding, Jérôme Gilleron, Virginie Magnone, Pascal Barbry, David Dombrowicz, Christophe Duranton, Abdelilah Wakkach, Claudine Blin‐Wakkach, Burkhard Becher, Sophie Pagnotta, Rafael J. Argüello, Pia Rantakari, Svetoslav Chakarov, Florent Ginhoux, Konstantin Zaitsev, Ki-Wook Kim, Laurent Yvan‐Charvet, Rodolphe Guinamard, Jesse W. Williams, Stoyan Ivanov
Abstract
macrophages located at the cortico-medullary junction. Macrophage sex dimorphism depends on the presence of the cortical X-zone. Adrenal gland macrophage depletion results in altered tissue homeostasis, modulated lipid metabolism, and decreased local aldosterone production during stress exposure. Overall, these data reveal the heterogeneity of adrenal gland macrophages and point toward sex-restricted distribution and functions of these cells.