Stereoselective Palladium-Catalyzed Hiyama Cross-Coupling Reaction of Tetrasubstituted <i>gem</i>-Difluoroalkenes
Min Li, Gavin Chit Tsui
Abstract
High Resolution Image Download MS PowerPoint Slide We herein describe a diastereoselective Pd(0)-catalyzed Hiyama cross-coupling reaction of gem -difluoroalkenes. The use of organosilicon reagents in this reaction is advantageous over other organometallic reagents by allowing the introduction of a wide range of functional groups, including challenging alkyl groups. Also conveniently, the additive TBAF was not required for (hetero)aryl-substituted difluoroalkenes.
Topics & Concepts
ChemistryOrganosiliconReagentArylCatalysisPalladiumStereoselectivityCoupling reactionAlkylCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods