CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway
Yann Deleye, Alexia K. Cotte, Sarah Anissa Hannou, Nathalie Hennuyer, Lucie Bernard, Bruno Derudas, Sandrine Caron, Vanessa Legry, Emmanuelle Vallez, Emilie Dorchies, Nathalie Martin, Steve Lancel, Jean‐Sébastien Annicotte, Kadiombo Bantubungi, Albin Pourtier, Violeta Raverdy, François Pattou, Philippe Lefèbvre, Corinne Abbadie, Bart Staels, Joel T. Haas, Réjane Paumelle
Abstract
and its target genes. Our findings demonstrate that p16 represses hepatic lipid catabolism during fasting and may thus participate in the preservation of metabolic flexibility.
Topics & Concepts
AMPKBeta oxidationChemistryPeroxisome proliferator-activated receptorPeroxisomeCell biologyAMP-activated protein kinaseCancer researchSignal transductionFatty acidInternal medicineBiochemistryKinaseProtein kinase ABiologyReceptorMedicineLiver Disease Diagnosis and TreatmentDiet and metabolism studiesMetabolism, Diabetes, and Cancer