Alpinoblonoids A and B, Two 16-<i>nor</i>-Labdane-Related Diterpenoids with a Tricyclic Carbon Skeleton from <i>Alpinia oblongifolia</i>
B. Zhang, Lu Gan, Yuwei Wu, Wenxian Li, Wen-Xian Li, De‐an Guo, Wei Li, Wei Li
Abstract
Alpinoblonoids A ( 1 ) and B ( 2 ), two 16- nor -labdane related diterpenoids featuring 2,6,6,10,11-pentamethyltricyclo[8.4.0.0 2,7 ]tetradecane and 11-ethyl-2,6,6,10-tetramethyltricyclo[8.3.0.0 2,7 ]tridecane skeletons, respectively, along with their biosynthetic precursor ( 3 ), were isolated from the rhizomes of Alpinia oblongifolia . Their structural elucidation was achieved by a variety of techniques, including spectroscopic and chemical methods, ECD calculations, as well as single-crystal X-ray diffraction. Compounds 1 and 2 exhibited antihepatic fibrosis activity by inhibiting the expressions of fibronectin, collagen I, and α-smooth muscle actin.
Topics & Concepts
LabdaneChemistryTricyclicCarbon skeletonDiterpeneSkeleton (computer programming)StereochemistryComputer scienceProgramming languageGinger and Zingiberaceae researchPhytochemistry and Biological ActivitiesPharmacological Effects of Natural Compounds