Mechanochemical synthesis of coumarins <i>via</i> Pechmann condensation under solvent-free conditions: an easy access to coumarins and annulated pyrano[2,3-<i>f</i>] and [3,2-<i>f</i>]indoles
Ainur D. Sharapov, Ramil F. Fatykhov, Igor А. Khalymbadzha, В.В. Шарутин, Sougata Santra, Grigory V. Zyryanov, Олег Н. Чупахин, Brindaban C. Ranu
Abstract
A green protocol has been developed for the synthesis of simple coumarins and linear pyrano[2,3- f ] and [3,2- f ]indoles by the reaction of phenol derivatives with β-ketoesters under ball milling at ambient temperature in the presence of methanesulfonic acid.
Topics & Concepts
Methanesulfonic acidChemistryPhenolCoumarinOrganic chemistrySolventCondensationPhysicsThermodynamicsSynthesis of Organic CompoundsMulticomponent Synthesis of HeterocyclesSynthesis and biological activity