Direct Dehydrogenative Access to Unsymmetrical Phenones
Congjun Yu, Raolin Huang, Frédéric W. Patureau
Abstract
The first non-directed dehydrogenative phenone coupling method of methylarenes with aromatic C-H bonds, displaying a large substrate scope, is herein reported. This reaction represents a far more direct atom- and step-efficient alternative to the classical Friedel-Crafts or Suzuki-Miyaura derived acylation reactions. The method can be carried out on a gram scale and was successfully applied to the synthesis of several Ketoprofen drug analogues.
Topics & Concepts
AcylationCombinatorial chemistryScope (computer science)Substrate (aquarium)KetoprofenChemistryComputer scienceCatalysisOrganic chemistryProgramming languageOceanographyGeologyChromatographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions