Liver-targeted degradation of BRD4 reverses hepatic fibrosis and enhances metabolism in murine models
Shengjie Yuan, Ayesha Nisar, Chuanjie Chen, Xin Dong, Yongzhang Pan, Meiting Zi, Qiong Wang, Sawar Khan, Yaxun Guo, Xuan Zhang, Yonghan He
Abstract
These results highlight the therapeutic potential of LIVTAC XZ1606 in reversing liver fibrosis and steatosis through targeted BRD4 degradation, offering a novel and selective approach for chronic liver disease treatment.
Topics & Concepts
FibrosisHepatic fibrosisLiver fibrosisCancer researchChemistryMetabolismMedicinePathologyCell biologyInternal medicineBiologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisChromatin Remodeling and Cancer