Structure optimization of an F-indole-chalcone (FC116) on 4-methoxyphenyl group and therapeutic potential against colorectal cancers with low cytotoxicity
Bolin Du, Xiaoxia Liu, Xin Luan, Weidong Zhang, Chunlin Zhuang
Topics & Concepts
In vivoChalconeCytotoxicityChemistryColorectal cancerPharmacologyIn vitroToxicityCancer researchReactive oxygen speciesCancerBiochemistryMedicineStereochemistryBiologyInternal medicineOrganic chemistryBiotechnologySynthesis and biological activityCancer therapeutics and mechanismsCancer Mechanisms and Therapy