An atomic resolution description of folic acid using solid state NMR measurements
Manasi Ghosh, Shovanlal Gayen, Krishna Kishor Dey
Abstract
s for the rest of the carbon nuclei sites. Spin lattice relaxation time varies from 416 s to 816 s. For C23 and C14, the value is 816 s, and it is 416 s for C7 nuclei. The correlation between structure and dynamics on an atomic scale of such an important drug as folic acid can be visualized by these types of extensive spectroscopic measurements, which will help to develop an advanced drug for DNA replication.
Topics & Concepts
ChemistryAnisotropyChemical shiftDipoleSpin–lattice relaxationRelaxation (psychology)CrystallographyNuclear magnetic resonancePhysical chemistryPhysicsOrganic chemistryNuclear quadrupole resonancePsychologySocial psychologyQuantum mechanicsAdvanced NMR Techniques and ApplicationsSolid-state spectroscopy and crystallographyInorganic Fluorides and Related Compounds