Birch Reduction of Arenes Using Sodium Dispersion and DMI under Mild Conditions
Sobi Asako, Ikko Takahashi, Takashi Kurogi, Yoshiaki Murakami, Laurean Ilies, Kazuhiko Takai
Abstract
Abstract An easy-to-handle sodium dispersion in paraffin oil (SD), in combination with inexpensive and environmentally benign 1,3-dimethyl-2-imidazolidinone (DMI) as an additive enables the Birch-type reduction of a variety of arenes with high yields, selectivity, and tolerance of functionality such as ether, alcohol, amine, amide, and carboxylic acid.
Topics & Concepts
ChemistryBirch reductionReduction (mathematics)SodiumDispersion (optics)Organic chemistryOpticsMathematicsPhysicsGeometryChemical Reactions and IsotopesCoordination Chemistry and OrganometallicsAsymmetric Hydrogenation and Catalysis