TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress
Sseu-Pei Hwang, Han Liao, Katherine Barondeau, Xinyi Han, Cassandra Herbert, Hunter McConie, Amirtha Shekar, Dimitri G. Pestov, Patrick A. Limbach, Jeffrey T. Chang, Catherine Denicourt
Abstract
G27 modification on tRNA Tyr, resolving a long-standing gap of knowledge and highlighting its potential role in a tRNA modification circuit crucial for translation regulation and stress response.
Topics & Concepts
Transfer RNATranslation (biology)Cell biologyRibosome biogenesisProtein biosynthesisT armBiologyRNA polymerase IIIMethyltransferaseRibosomeTyrosineBiochemistryRNAChemistryMessenger RNAMethylationGeneRNA polymeraseRNA modifications and cancerCancer-related gene regulationCardiac Structural Anomalies and Repair