A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine
Jianyong Li, Zhenhua Li, Yanzhi Dou, Jing Su, Jiye Shi, Yi Zhou, Lihua Wang, Shiping Song, Chunhai Fan
Abstract
A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine. The microfluidic electrochemical biochip holds promise to become a practical device for medical diagnosis, especially POCT.
Topics & Concepts
BiochipNano-MicrofluidicsPoint of careNanotechnologyPoint-of-care testingCreatinineChromatographyChemistryMaterials scienceComputer scienceBiochemistryMedicinePathologyComposite materialBiosensors and Analytical DetectionElectrochemical sensors and biosensorsMicrofluidic and Capillary Electrophoresis Applications