Rapid metagenomics for diagnosis of bloodstream and respiratory tract nosocomial infections: current status and future prospects
Lluís Moragues-Solanas, Riccardo Scotti, Justin O’Grady
Abstract
CMg approaches are more accurate in LRTI compared to BSI. This is because BSIs are caused by low pathogen numbers in a high background of human cells. To overcome this, most approaches focus on cell-free DNA, but, to date, these tests are not accurate enough yet to replace blood culture. The higher pathogen numbers in LRTI samples make this a more suitable for CMg and accurate approaches have been developed, which are likely to be implemented in hospitals within the next 2-5 years.
Topics & Concepts
MetagenomicsIntensive care medicineAntimicrobial stewardshipBlood cultureMedicineBloodstream infectionRespiratory tract infectionsLower respiratory tract infectionPathogenHealth careBiologyImmunologyAntibiotic resistanceMicrobiologyAntibioticsInternal medicineRespiratory systemBiochemistryEconomicsGeneEconomic growthBacterial Identification and Susceptibility TestingAntibiotic Resistance in BacteriaNosocomial Infections in ICU