IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca <sup>2+</sup> through the noncanonical STAT3 pathway
Felipe Valença-Pereira, Qian Fang, Isabelle Marié, Emily Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David E. Levy, Mercedes Rincón
Abstract
Significance In this manuscript, we identify a pathway involving mitochondrial Ca 2+ and mitochondrial Stat3 that strengthens the motility fitness of activated CD4 T cells. Considering that motility is essential for CD4 T cells to find and reach their targets and mediate pathogenesis, these findings could lead to the development of therapeutic strategies to intervene in CD4 T cell–mediated inflammatory diseases.
Topics & Concepts
MotilitySTAT3Cell biologyBiologyMitochondrionCellTranscription factorChemistrySignal transductionGeneBiochemistryT-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsImmune Cell Function and Interaction