piR-16404 drives ferroptotic liver injury via CASTOR1/mTORC1/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamide
Wanli Ma, Xiaoyu Huo, Ruoxi Li, Jingjing Xing, Lin Xu, Dianke Yu
Topics & Concepts
GPX4In vivoLipid peroxidationChemistryLiver injuryToxicityIn vitroCell biologyCancer researchGlutathionePharmacologyProgrammed cell deathMitochondrionApoptosisMechanism (biology)Reactive oxygen speciesDownregulation and upregulationArginineBiochemistryLiver toxicityCell cultureHepatocyteOxidative phosphorylationSignal transductionRNA modifications and cancerMicroRNA in disease regulationFerroptosis and cancer prognosis