Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development
Stefanie Scherer, Susanne Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina von Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christoph Mayer, Percy A. Knolle, Martin Klingenspor, Valeria Fumagalli, Matteo Iannacone, Martin Prlic, Thomas Korn, Erika L. Pearce, Thomas Höfer, Anna M. Schulz, Dietmar Zehn
Topics & Concepts
EffectorPyrimidineCell biologyDihydroorotate dehydrogenaseT cellBiologyMemory T cellChemistryImmunologyBiochemistryImmune systemImmune Cell Function and InteractionCAR-T cell therapy researchBiochemical and Molecular Research