Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients
Lucilla Fabbri, Maeva Dufies, Sandra Lacas‐Gervais, Betty Gardie, Sophie Gad, Julien Parola, Nicolas Nottet, Monique Meyenberg Cunha de Padua, Julie Contenti, Delphine Borchiellini, Jean-Marc Ferrero, Nathalie Leclercq, Damien Ambrosetti, Baharia Mograbi, Stéphane Richard, Julien Viotti, Emmanuel Chamorey, Nirvana Sadaghianloo, Matthieu Rouleau, William J. Craigen, Bernard Mari, Stéphan Clavel, Gilles Pagès, Jacques Pouysségur, Frédéric Bost, Nathalie M. Mazure
Abstract
: This study provides a new way to classify ccRCC patients and proposes potential therapeutic targets linked to metabolism and immunotherapy.
Topics & Concepts
CiliogenesisRenal cell carcinomaIdentification (biology)CellVDAC1Clear cell renal cell carcinomaCancer researchCiliumBiologyCell biologyChemistryPathologyMedicineInternal medicineBiochemistryGeneBotanyEscherichia coliBacterial outer membraneGenetic and Kidney Cyst DiseasesRenal and related cancersRenal cell carcinoma treatment