Ryanodine receptor leak triggers fiber Ca <sup>2+</sup> redistribution to preserve force and elevate basal metabolism in skeletal muscle
C. R. Lamboley, Luke Pearce, Crystal Seng, Aldo Meizoso‐Huesca, Daniel P. Singh, Barnaby P. Frankish, Vikas Kaura, Harriet P. Lo, Charles Ferguson, Paul D. Allen, Philip M. Hopkins, Robert G. Parton, Robyn M. Murphy, Chris van der Poel, C. J. Barclay, Bradley S. Launikonis
Abstract
RyR1 Ca 2+ leak causes a cascade of events that shifts Ca 2+ to the cytoplasm and mitochondria, supporting force generation.
Topics & Concepts
RYR1Ryanodine receptorMalignant hyperthermiaEndoplasmic reticulumSkeletal muscleDantroleneCell biologyChemistryLeakBiophysicsMitochondrionBiologyCalciumInternal medicineEndocrinologyMedicinePathologyEngineeringEnvironmental engineeringIon channel regulation and functionGenetic Neurodegenerative DiseasesAdipose Tissue and Metabolism