Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia
Kehui Zhang, Rui Huang, Ming Ji, Songwen Lin, Fangfang Lai, Deyu Wu, Hua Tian, Jinhui Bi, Shouguo Peng, Jiaqi Hu, Sheng Li, Yan Li, Xiaoguang Chen, Heng Xu
Topics & Concepts
ChemistryBenzamidePharmacophorePI3K/AKT/mTOR pathwayIn vivoAcetylationPharmacologyMyeloid leukemiaCancer researchBiochemistryApoptosisStereochemistryBiologyBiotechnologyGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsSynthetic Organic Chemistry Methods