Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression
Kai‐Fu Chang, Xiao‐Fan Huang, Jinghua Tsai Chang, Ya‐Chih Huang, Wei-Syuan Lo, Chih‐Yen Hsiao, Nu‐Man Tsai
Abstract
-methlyguanine-DNA-methyltransferase (MGMT), multidrug resistance protein 1 (MDR1), and CD133 in TMZ-treated GBM cells. In the animal study, the combination treatment significantly suppressed tumor growth through the induction of cell apoptosis and decreased TMZ drug resistance. Moreover, cedrol-treated mice exhibited no significant differences in body weight and improved TMZ-induced liver damage. These results imply that cedrol may be a potential novel agent for combination treatment with TMZ for GBM therapy that deserves further investigation.
Topics & Concepts
TemozolomideApoptosisDNA damagePharmacologyCell cycle checkpointIn vivoProtein kinase BCancer researchChemistryDrug resistanceMAPK/ERK pathwayCell cycleCell growthCell cultureBiologySignal transductionGliomaBiochemistryDNAMicrobiologyGeneticsCancer therapeutics and mechanismsMicrotubule and mitosis dynamicsDNA Repair Mechanisms