Association of neutrophil extracellular traps with the production of circulating DNA in patients with colorectal cancer
Brice Pastor, Jean-Daniel Abraham, Ekaterina Pisareva, Cynthia Sánchez, Andrei Kudriavstev, Rita Tanos, Alexia Mirandola, Lucia Mihalovičová, Véronique Pezzella, Antoine Adenis, Marc Ychou, Thibault Mazard, Alain R. Thierry
Abstract
< 0.0001) than in HI (N = 114). These three NETs markers may readily distinguish between patients with mCRC from HI, (0.88, 0.86, 0.84, and 0.95 AUC values for NE, MPO, cirDNA, and NE + MPO + cirDNA, respectively). Concomitant analysis of anti-phospholipid (anti-cardiolipin), NE, MPO, and cirDNA plasma concentrations in patients with mCRC might have value for thrombosis prevention, and suggested that NETosis may be a critical factor in the immunological response/phenomena linked to tumor progression.
Topics & Concepts
Neutrophil extracellular trapsMyeloperoxidaseColorectal cancerNeutrophil elastaseInternal medicineElastaseCancerMedicineChemistryImmunologyGastroenterologyOncologyCancer researchEnzymeBiochemistryInflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsBlood disorders and treatmentsImmune cells in cancer