Altered brain activity and cognitive impairment in patients with psoriasis
Xiaoping Yi, Xueying Wang, Yan Fu, Yan Luo, Jing Wang, Zaide Han, Yehong Kuang, Xiang Chen, Bihong T. Chen
Abstract
Abstract Background Patients with psoriasis may have cognitive impairment. However, there is limited information regarding intrinsic brain activity and cognitive function in patients with psoriasis. Objectives This study aim to assess alterations of intrinsic brain activity and its association with cognitive function in patients with psoriasis. Methods A total of 222 patients with psoriasis aged 18–70 years and 144 age and gender‐matched healthy controls (HCs) were enrolled into this study. All subjects underwent brain resting‐state functional magnetic resonance imaging (rs‐fMRI) and neuropsychological testing. The rs‐fMRI data were analysed for both intrinsic brain activity as indicated by amplitude of low‐frequency fluctuation (ALFF) and seed‐based functional connectivity (FC). Correlative analysis of brain activity with cognitive assessment was performed. Results Compared with the HCs, patients with psoriasis had worse cognitive performance in the Trail Making Test, Digit Span Test and Stroop Color‐Word Test ( p < 0.05). Patients with psoriasis showed decreased ALFF in the left superior frontal gyrus, the left medial superior frontal gyrus and the right precuneus gyrus; as well as enhanced ALFF in the left paracentral lobule ( p FWE < 0.05). Significant correlations were noted between the altered ALFF in the four brain regions and cognitive assessment ( p < 0.05). Moreover, patients with psoriasis had increased FC between the four brain regions with altered ALFF (seeds) and the left prefrontal gyrus, the left anterior cingulate gyrus, left superior parietal lobule and default mode network (DMN) regions such as the right precuneus gyrus, left inferior parietal lobule, right angular gyrus and bilateral inferior temporal gyrus ( p FWE < 0.05). Conclusions Patients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN–prefrontal circuit. These brain changes may be the underlying neural correlates for cognitive functioning in patients with psoriasis.