C<sub>60</sub>-β-cyclodextrin conjugates for enhanced nucleus delivery of doxorubicin
Rohin Biswas, Shilong Yang, Ryan A. Crichton, Patrick Adly-Gendi, Tyler K. Chen, William P. Kopcha, Zheng Shi, Jianyuan Zhang
Abstract
cage was trapped in the lysosome for a longer time and showed significantly reduced doxorubicin delivery to the nucleus. This study opens new paths towards advanced fullerene-based DDSs for small molecule drugs.
Topics & Concepts
DoxorubicinLysosomeConjugateFullereneNucleusDrug deliveryChemistryCyclodextrinBiophysicsCageNanotechnologyMaterials scienceBiochemistryOrganic chemistryBiologyCell biologyEnzymeCombinatoricsMathematical analysisMathematicsGeneticsChemotherapyFullerene Chemistry and ApplicationsGraphene research and applicationsGraphene and Nanomaterials Applications